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  • ISBN-13: 9781565125537
  • ISBN-10: 1565125533

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Publishers Weekly Reviews

Publishers Weekly® Reviews

  • Reviewed in: Publishers Weekly, page 46.
  • Review Date: 2008-04-14
  • Reviewer: Staff

This densely researched report adds to the growing literature on Big Pharma’s efforts to sell blockbuster drugs and with its two crusading heroes seems ready for Hollywood. Expanding on her reporting for the Boston Globe, Bass focuses on psychiatrist Martin Teicher, who as early as 1988 noticed that the antidepressant Prozac seemed paradoxically to cause suicidal thoughts in his patients, and the nearly blind Rose Firestein, a lawyer in the New York State attorney general’s office who was investigating the inappropriate marketing and use of Paxil for unapproved purposes. Drug companies insisted there was “no scientific evidence whatsoever” linking GlaxoSmithKline’s Paxil, Ely Lilly’s Prozac and other serotonin-increasing antidepressants to suicidal thoughts and behavior, and Bass describes the dogged battle to show that company researchers had deliberately suppressed the results of trials with negative outcomes. Bass also follows the story of Tonya Brooks, an unhappy teenager who attempted suicide while taking Paxil. Although the story sometimes gets lost in the details of then attorney general Eliot Spitzer’s 2004 suit against GlaxoSmithKline (eventually settled for $2.5 million), this story of determined do-gooders is inspiring. (June)

BookPage Reviews

Popping the image of a popular pill

One sad lesson to be learned from Side Effects: when you're considering whether to take a new medication, don't assume anything. Don't assume the medical researchers didn't manipulate their findings. Or that the pharmaceutical company released all its data. Or that the Food and Drug Administration made sure the medicine is safe. Alison Bass, a former Boston Globe reporter who specializes in medical issues, delivers that tough truth through the tale of Paxil, a popular antidepressant widely prescribed for children and adolescents—before it became clear that Paxil and similar drugs increase suicidal thoughts among some pediatric patients. The FDA now requires warning labels on those medications, but that step came only after a struggle between "Big Pharma" and patient advocates.

Bass focuses on a precedent-setting legal case brought by the New York State Attorney General's Office against GlaxoSmithKline, accusing the company of hiding negative findings about Paxil. She humanizes the somewhat complex story through the experiences of a handful of dogged whistleblowers: a legally blind prosecutor who noticed the data in a key Paxil study didn't match its positive conclusion; a health care administrator who stumbled over what Bass says were research misdeeds at Brown University; and a psychiatrist who first reported in 1990 that some patients became suicidal after they were prescribed Prozac.

The whistleblowers' persistence has paid off to some extent. The FDA has become somewhat more vigilant, and medical journals are more careful about the research they publish. But Bass shows that ethically dubious financial ties between pharmaceutical companies and the medical research community continue unabated. Her prime example is a senior psychiatrist at Brown implicated in questionable practices in the Paxil case and others. He refused to speak to Bass, and remains in good standing at Brown.

Anne Bartlett is a journalist in Washington, D.C.

BAM Customer Reviews