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Johnny Galecki (ROSEANNE) and Jim Parsons (JUDGING AMY) star as Leonard and Sheldon, two socially inept scientists who, while accustomed to probing the secrets of the universe, are totally unprepared for the greatest mystery of all: women. When a beautiful blonde, Penny (Kaley Cuoco), moves next door and invades their dweebish den, these friends have their lives turned upside down. Plenty of hijinks are in store for the two roommates as they get a crash course in the ways of the opposite sex. In the second season, both Leonard and Sheldon find love, but will they also find the answers to complex astrophysics equations?