"The truth is, not one of us is innocent. We all have sins to confess." So reveals Catherine de Medici, the last legitimate descendant of her family's illustrious line. Expelled from her native Florence, Catherine is betrothed to Henri, son of Francois I of France. In an unfamiliar realm, Catherine strives to create a role for herself through her patronage of the famous clairvoyant Nostradamus and her own innate gift as a seer. But in her fortieth year, Catherine is widowed, left alone with six young children in a kingdom torn apart by the ambitions of a treacherous nobility. Relying on her tenacity, wit, and uncanny gift for compromise, Catherine seizes power, intent on securing the throne for her sons, unaware that if she is to save France, she may have to sacrifice her ideals, her reputation, and the secret of her embattled heart.