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Innate Immune Regulation and Cancer Immunotherapy
by Rong-Fu Wang


Overview -

Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression.  Read more...


 
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More About Innate Immune Regulation and Cancer Immunotherapy by Rong-Fu Wang
 
 
 
Overview

Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.



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Details
  • ISBN-13: 9781441999139
  • ISBN-10: 1441999132
  • Publisher: Springer
  • Publish Date: December 2011
  • Page Count: 478
  • Dimensions: 9.2 x 6.2 x 1.2 inches
  • Shipping Weight: 1.8 pounds


Related Categories

Books > Medical > Immunology
Books > Medical > Oncology
Books > Medical > Pharmacology

 
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