The Self-Organizing Map (SOM), with its variants, is the most popular artificial neural network algorithm in the unsupervised learning category. Many fields of science have adopted the SOM as a standard analytical tool: in statistics,signal processing, control theory, financial analyses, experimental physics, chemistry and medicine. A new area is organization of very large document collections. The SOM is also one of the most realistic models of the biological brain functions. This new edition includes a survey of over 2000 contemporary studies to cover the newest results; the case examples were provided with detailed formulae, illustrations and tables; a new chapter on software tools for SOM was written, other chapters were extended or reorganized.