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Analysis of Single-Cell Data : Ode Constrained Mixture Modeling and Approximate Bayesian Computation
by Carolin Loos
Overview
Carolin Loos introduces two novel approaches for the analysis of single-cell data. Both approaches can be used to study cellular heterogeneity and therefore advance a holistic understanding of biological processes. The first method, ODE constrained mixture modeling, enables the identification of subpopulation structures and sources of variability in single-cell snapshot data. The second method estimates parameters of single-cell time-lapse data using approximate Bayesian computation and is able to exploit the temporal cross-correlation of the data as well as lineage information.
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Details
- ISBN-13: 9783658132330
- ISBN-10: 3658132337
- Publisher: Springer Spektrum
- Publish Date: March 2016
- Dimensions: 8.27 x 5.83 x 0.28 inches
- Shipping Weight: 0.35 pounds
- Page Count: 92
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