{ "item_title" : "Decoding the Genomic Control of Immune Reactions", "item_author" : [" Gregory R. Bock", "Jamie A. Goode "], "item_description" : "This book explores existing and potential strategies for using thegenome sequences of human, mouse, other vertebrates and humanpathogens to solve key problems in the treatment of immunologicaldiseases and chronic infections. The assembled genomesequences now provide important opportunities for solving theseproblems, but a major bottleneck is the identification of keysequences and circuits controlling the relevant immunereactions. This will require innovative, interdisciplinary andcollaborative strategies of a scale and complexity we are only nowbeginning to comprehend. Specific problems addressed include the following: What kinds of information are we lacking to understand how thegenome sequence specifies the differentiation and response ofimmune system cells, and system behaviour such as immunologicalmemory and tolerance?Which genome sequences and cellular circuits cause or preventpathological immune responses to foreign pathogens, allergens orself-tissues?Which host and pathogen genome sequences and cellular circuitsexplain the failure of sterilizing immune responses tosophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses?Containing contributions from a range of leading experts in thefield, this book provides an important new perspective for clinicalimmunologists and basic researchers alike.", "item_img_path" : "https://covers3.booksamillion.com/covers/bam/0/47/002/755/047002755X_b.jpg", "price_data" : { "retail_price" : "211.95", "online_price" : "211.95", "our_price" : "211.95", "club_price" : "211.95", "savings_pct" : "0", "savings_amt" : "0.00", "club_savings_pct" : "0", "club_savings_amt" : "0.00", "discount_pct" : "10", "store_price" : "" } }

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