{ "item_title" : "Formulation and Development of Bilayer Floating Tablets of Nifedipine", "item_author" : [" Dinesh Kumar Sharma", "Amulyaratna Behera", "Gurudutta Pattnaik "], "item_description" : "The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.", "item_img_path" : "https://covers2.booksamillion.com/covers/bam/6/20/341/087/620341087X_b.jpg", "price_data" : { "retail_price" : "59.29", "online_price" : "59.29", "our_price" : "59.29", "club_price" : "59.29", "savings_pct" : "0", "savings_amt" : "0.00", "club_savings_pct" : "0", "club_savings_amt" : "0.00", "discount_pct" : "10", "store_price" : "" } }

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