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{ "item_title" : "Formulation of Film Coated Tablets of Norfloxacin and Tinidazole", "item_author" : [" Anilkumar Shinde", "Harinath More "], "item_description" : "The aim of the present study was development and optimization of an efficacious, pharmaco-economical, palatable and marketable film coated tablet formulation of Norfloxacin-Tinidazole. Bitter taste of both drugs reduces the patient compliance & hence marketability. However it has been shown that film coating technology economical & useful in masking the taste. The core tablets with maximum hardness & minimum disintegration time were selected for film coating. (F-1 & F-07) The optimized formulation F-07 showed hardness, friability, disintegration time and drug release in range 9 kg/cm2, 0.17 0.02%, 27.40 2.1 sec. & 100% release in 30 min. respectively. For all tablet formulation drug release at the end of 30 min was found in the range of 52.78 0.09 to 100.07 0.5 % and from the obtained results, F-07 was selected as an optimized formulation for designing palatable tablet. Therefore it can be concluded that the present work discusses in depth the development and optimization of an efficacious, pharmaco-economical, palatable and marketable tablet formulation of Norfloxacin and Tinidazole.", "item_img_path" : "https://covers2.booksamillion.com/covers/bam/6/13/997/736/6139977363_b.jpg", "price_data" : { "retail_price" : "59.29", "online_price" : "59.29", "our_price" : "59.29", "club_price" : "59.29", "savings_pct" : "0", "savings_amt" : "0.00", "club_savings_pct" : "0", "club_savings_amt" : "0.00", "discount_pct" : "10", "store_price" : "" } }
Formulation of Film Coated Tablets of Norfloxacin and Tinidazole|Anilkumar Shinde

Formulation of Film Coated Tablets of Norfloxacin and Tinidazole

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Overview

The aim of the present study was development and optimization of an efficacious, pharmaco-economical, palatable and marketable film coated tablet formulation of Norfloxacin-Tinidazole. Bitter taste of both drugs reduces the patient compliance & hence marketability. However it has been shown that film coating technology economical & useful in masking the taste. The core tablets with maximum hardness & minimum disintegration time were selected for film coating. (F-1 & F-07) The optimized formulation F-07 showed hardness, friability, disintegration time and drug release in range 9 kg/cm2, 0.17 0.02%, 27.40 2.1 sec. & 100% release in 30 min. respectively. For all tablet formulation drug release at the end of 30 min was found in the range of 52.78 0.09 to 100.07 0.5 % and from the obtained results, F-07 was selected as an optimized formulation for designing palatable tablet. Therefore it can be concluded that the present work discusses in depth the development and optimization of an efficacious, pharmaco-economical, palatable and marketable tablet formulation of Norfloxacin and Tinidazole.

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Details

  • ISBN-13: 9786139977369
  • ISBN-10: 6139977363
  • Publisher: LAP Lambert Academic Publishing
  • Publish Date: December 2018
  • Dimensions: 9 x 6 x 0.23 inches
  • Shipping Weight: 0.33 pounds
  • Page Count: 96

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