{ "item_title" : "Genetically Modified Animal Models in Biomedical Research", "item_author" : [" Pramod Kumar R.", "Mukesh Kumar Gupta", "Ramachandra S. G. "], "item_description" : "Genetically modified (GM) animal models have transformed biomedical research by offering robust tools to explore gene functionality, disease mechanisms, and treatment strategies. Advances in genome engineering methodologies, especially CRISPR/Cas systems, has empowered researchers to accurately introduce, alter, or eliminate specific genetic sequences, resulting in animal models that closely replicate human biology and pathology. The book 'Genetically Modified Animal Models in Biomedical Research' offers a comprehensive overview of the principles, techniques, and various uses of GM animal models in modern life sciences. The book addresses a wide array of species, including invertebrates, rodents, large animals, and non-human primates, focusing on their application in infectious diseases, cancer, metabolic and neurological disorders, cardiovascular and reproductive diseases, immunology, xenotransplantation, drug development, and the development of therapeutic biomolecules. It further examines recent progress in genome editing technology, ethical implications, regulatory framework, and the best practices for the responsible use of GM animals in research. Authored by experts in the domain, this publication serves as a definitive reference for researchers, academicians, graduate students, and professionals engaged in biomedical, translational, and preclinical studies. It offers both fundamental concepts and practical insights, rendering it an indispensable reference for anyone aiming to employ GM animal models to advance scientific discovery and enhance human and animal well-being.", "item_img_path" : "https://covers1.booksamillion.com/covers/bam/9/81/925/248/9819252482_b.jpg", "price_data" : { "retail_price" : "219.99", "online_price" : "219.99", "our_price" : "219.99", "club_price" : "219.99", "savings_pct" : "0", "savings_amt" : "0.00", "club_savings_pct" : "0", "club_savings_amt" : "0.00", "discount_pct" : "10", "store_price" : "" } }

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