{ "item_title" : "Hif-1 as a Potential Drug Target for Solid Tumors", "item_author" : [" Sonal Manohar", "Kinjal Majithiya", "Palak Guralwar "], "item_description" : "Hypoxia is a typical microenvironmental characteristic of many solid tumors. HIF-1 is the key regulator of growing tumor's response to hypoxia. HIF-1α subunit levels rise in hypoxic environments, when oncogenes are activated, and/or when tumor suppressor genes are inactivated, this is necessary for HIF-1 function in tumors. HIF-1 turns on genes that enable cells of a solid tumor to flourish in the noxious hypoxic tumor environment via attainment of numerous cancer hallmarks. This book elaborates the regulation and role of HIF-1 in oncogenic signalling. Further, its potential as a drug target for solid tumors is also discussed. The book will be useful as a reference book for students of graduate and post-graduate level courses in Life Science, Biomedical Science as well as to those who have a special interest in Cancer Biology.", "item_img_path" : "https://covers1.booksamillion.com/covers/bam/6/20/801/067/6208010675_b.jpg", "price_data" : { "retail_price" : "66.00", "online_price" : "66.00", "our_price" : "66.00", "club_price" : "66.00", "savings_pct" : "0", "savings_amt" : "0.00", "club_savings_pct" : "0", "club_savings_amt" : "0.00", "discount_pct" : "10", "store_price" : "" } }

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