{ "item_title" : "High Content Screening", "item_author" : [" Paul A. Johnston", "Oscar J. Trask "], "item_description" : "Part I: Reagents and Kits for Measuring Cells and their Phenotypes 1. Applications and Caveats on the Utilization of DNA-specific Probes in Cell-based AssaysRoy Edward2. General Staining and Segmentation Procedures for High Content Imaging and Analysis Kevin M Chambers, Bhaskar S Mandavilli, Nick J Dolman and Michael S Janes3. Tools to Measure Cell Health and Cytotoxicity Using High Content Imaging and AnalysisBhaskar S Mandavilli, Robert J Aggeler, and Kevin Chambers4. Cell-based High Content Analysis of Cell Proliferation and ApoptosisBhaskar S Mandavilli, Michelle Yann and Scott Clarke5. Tools to Measure Autophagy using High Content Imaging and Analysis Nick J Dolman, Brent A. Samson, Kevin M. Chambers, Michael S Janes, and Bhaskar S MandavilliPart II: Selecting Microtiter Plates, Identify Imaging Artifacts, Rnai Specificity, Data Handling, Kinetic Assays, and Ultra-High Throughput HCS6. Guidelines for Microplate Selection in High Content Imaging O.J. Trask7. Quality Control for High-Throughput Imaging Experiments using Machine Learning in CellProfiler Mark-Anthony Bray and Anne E. Carpenter8. High Content Screening Approaches That Minimize Confounding Factors in RNAi, CRISPR and Small Molecule Screening Steven A. Haney9. Strategies and solutions to Maintain and Retain Data from High Content Imaging, Analysis, and Screening Assays Karol Kozak, Bernt Rinn, Oliver Leven, and M. Emmenlauer10. Live-Cell High Content Screening in Drug Development Milan Esner, Felix Meyenhofer, and Marc Bickle11. Challenges and Opportunities in Enabling High-Throughput, Miniaturized High-Content Screening Debra Nickischer, Lisa Elkin, Normand Cloutier, Jonathan O'Connell, Martyn Banks, and Andrea WestonPart III: Harnessing Translocation, Signaling Pathways, Single Cell Analysis, and Multidimensional Data for Phenotypic Analysis 12. Translocation Biosensors - Versatile Tools To Probe Protein Functions In Living Cells Verena Fetz, Roland H. Stauber, and Shirley K. Knauer13. High Content Positional Biosensor Assay to Screen for Compounds that Prevent or Disrupt Androgen Receptor and Transcription Intermediary Factor 2 Protein-Protein Interactions Yun Hua, Daniel P. Camarco, Christopher J. Strock, and Paul A. Johnston14. High Content Imaging Assays for IL-6-induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines Paul A. Johnston, Malabika Sen, Yun Hua, Daniel Camarco, Tong Ying Shun, John S. Lazo, and Jennifer R. Grandis15. Single Cell and Population Level Analysis of HCA Data David Novo, Kaya Ghosh, and Sean Burke16. Utilization of Multidimensional Data in the Analysis of Ultra High Throughput High Content Phenotypic ScreensJudith Wardwell-Swanson and Yanhua HuSection IV: Phenotypic Models - Primary Neurons, Neural Stem/Progenitor Cells, Induced-Pluripotent Stem Cells, Multicellular Tumor Spheroids, Endothelial/Mesenchymal Stem Cell Co-Cultures, and Zebrafish Embryos17. High Content Screening of Mammalian Primary Cortical Neurons Dario Motti, Murray Blackmore, John Bixby, and Vance Lemmon18. Human Derived Neurons and Neural Progenitor Cells in High Content Imaging Applications Joshua A. Harrill19. Determination of Hepatotoxicity in iPSC-Derived Hepatocytes by Multiplexed High-Content AssaysOksana Sirenko and Evan F. Cromwell20. The Generation of Three-Dimensional Head and Neck Cancer Models for Drug Discovery in 384-well Ultra-Low Attachment Microplates David A. Close", "item_img_path" : "https://covers1.booksamillion.com/covers/bam/1/49/397/355/149397355X_b.jpg", "price_data" : { "retail_price" : "159.99", "online_price" : "159.99", "our_price" : "159.99", "club_price" : "159.99", "savings_pct" : "0", "savings_amt" : "0.00", "club_savings_pct" : "0", "club_savings_amt" : "0.00", "discount_pct" : "10", "store_price" : "" } }

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