{ "item_title" : "Photomodulation of Supramolecular Systems Containing Bioactive Small Molecules and Biopolymers", "item_author" : [" Johannes Karcher "], "item_description" : "Molecular photoswitches can change their conformation upon irradiation with light and convert this molecular movement into macroscopic changes of sophisticated materials. By combining state-of-the-art azobenzenes with supramolecular low-molecular-weight gelators, based on cyclic dipeptides, photomodulation of hydrogels was achieved. Photochromic amino acids with structures related to the natural L-phenylalanine were an essential element. The supramolecular hydrogels are multi-responsive towards pH, ions, temperature, and, in particular, light. Hereby the gelator F2-PAP-DKP-Lys can be turned into a sol upon irradiation with green light and within this transition a drug, for example an antibiotic, was released. The further improved supergelator Cl4-PAP-DKP-Lys2 is reversibly switchable with red and violet light in the range of 0.2-0.5 % in an isotonic Ringer's solution. At a concentration of 1 %, the hydrogel consisting of Cl4-PAP-DKP-Lys2 remains stable in a boiling water bath. Thus, we envision that the enhanced stability of the supramolecular assembly of Cl4-PAP-DKP-Lys2 and orthogonal biocompatibility of F2-PAP-DKP-Lys, could enable further applications, spanning from regenerative medicine to electronic devices, besides our future vision towards photopharmacology.", "item_img_path" : "https://covers3.booksamillion.com/covers/bam/3/83/255/099/3832550992_b.jpg", "price_data" : { "retail_price" : "94.00", "online_price" : "94.00", "our_price" : "94.00", "club_price" : "94.00", "savings_pct" : "0", "savings_amt" : "0.00", "club_savings_pct" : "0", "club_savings_amt" : "0.00", "discount_pct" : "10", "store_price" : "" } }

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