{ "item_title" : "Radiation Biology", "item_author" : [" Barry S. Rosenstein", "Jerome M. Karp "], "item_description" : "Radiation Biology: Molecular Foundations and Clinical Applications explores the effects of ionizing radiation on a molecular scale, with a focus on radiobiological principles relevant to cancer radiotherapy.The book starts at the subcellular level, elucidating the interactions between radiation and important cellular macromolecules, then gradually moves toward larger scales, demonstrating how the effects of radiation on macromolecules result in changes to the cell, which in turn lead to either cure or control of a cancer, or alternatively injury to normal tissues and organs. Topics covered include radiation-induced DNA damage and repair; effects of radiation on cellular signaling and cell death; quantification of cell kill and the effects of oxygen, linear energy transfer, radiosensitizers, and radioprotectors; models of radiation-induced tissue damage; the role of fractionation and dose rate; radiation-induced mutagenesis; and whole-body effects of radiation. Active areas of current research in radiation biology are discussed, including the use of radiation with immune-modulating agents, bystander effects, novel mechanisms of radiation-induced cell death, FLASH radiotherapy, personalized assays for prediction of radiation effects, nanoparticle delivery of radiosensitizers, and GRID/LATTICE radiotherapy. The last section of the book provides a review of cancer biology, discussing cancer genetics and epigenetics, the role of the tumor microenvironment, tumor metabolism, chemotherapy, and immunotherapy.", "item_img_path" : "https://covers2.booksamillion.com/covers/bam/0/44/313/468/0443134685_b.jpg", "price_data" : { "retail_price" : "165.00", "online_price" : "165.00", "our_price" : "165.00", "club_price" : "165.00", "savings_pct" : "0", "savings_amt" : "0.00", "club_savings_pct" : "0", "club_savings_amt" : "0.00", "discount_pct" : "10", "store_price" : "" } }

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