{ "item_title" : "Regulation of Cancer Immune Checkpoints", "item_author" : [" Jie Xu "], "item_description" : "Introduction.- Molecular and cellular functions of CTLA-4 pathway.- Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond.- Discovery of new immune checkpoints: family grows up.- Mechanisms of resistance to checkpoint blockade therapy.- Molecular events behind adverse effects.- Rational discovery of response biomarkers.- Spatiotemporal changes in checkpoint molecule expression.- Functions of checkpoint molecules beyond immune evasion.- Genetic alterations and checkpoint expression.- Regulations on messenger RNA: wires and nodes.- Folded or degraded in endoplasmic reticulum.- Mono- and poly-ubiquitination: tags for fates.- Lysosome as the black hole for checkpoint molecules.- Phosphorylation: a fast switch for checkpoint signalling.- Palmitoylation as a signal for delivery.- Checkpoints under traffic control: from and to organelles.- Exosome and secretion: action on?.- Macromolecules and antibody-based drugs.- Mechanisms inspired targeting peptides.- Small molecular inhibitors.- Therapeutic development of immune checkpoint blockers.- Concluding remarks", "item_img_path" : "https://covers3.booksamillion.com/covers/bam/9/81/153/265/9811532656_b.jpg", "price_data" : { "retail_price" : "219.99", "online_price" : "219.99", "our_price" : "219.99", "club_price" : "219.99", "savings_pct" : "0", "savings_amt" : "0.00", "club_savings_pct" : "0", "club_savings_amt" : "0.00", "discount_pct" : "10", "store_price" : "" } }

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