{ "item_title" : "Research on Antitumor Drug Targets and Toxicities/抗", "item_author" : [" [美]金毅 主Ņ "], "item_description" : "Leading the way in antitumor drug R&D - solving the great challenges of life science引领抗肿瘤药物研发，破解生命科学难题！ Treating tumors with targeted therapies is one of the most remarkable scientific achievements in the field of innovative drug R&D over the past 30 years. This book selects 27 of the most common targets in the current field of antitumor targeted drug development and nearly 100 representative drugs that have been approved for marketing. For each target, the book provides a detailed introduction to its molecular structure and mechanism of action, the history of drug development for that target type, and basic information on currently approved drugs. It then systematically presents the nonclinical and clinical study data for representative drugs of each target, including pharmacokinetics, toxicology, and clinical adverse reactions. The book analyzes the correlation between nonclinical and clinical safety data for these representative drugs, elucidates the mechanisms underlying their major toxicities, and finally offers perspectives on the future development of drugs targeting the same class. This book not only provides detailed research information on targeted drugs for drug discovery researchers but also offers safety data on various targeted therapies for clinicians. It serves as a valuable reference for researchers in related fields. 通过特定的靶向药物来治疗肿瘤是近30年来创新药研发领域最引人注目的科学成就之一。本书精选了目前抗肿瘤靶向药物研发领域最常见的27个靶点和已上市的近100个代表性药物，详细介绍了每个靶点的分子结构和作用机制、该类靶点药物研发的历史，以及目前已获批上市药物的基本信息，继而梳理了每个靶点代表性药物的非临床和临床研究数据，包括药代动力学和毒理学及临床的不良反应等，分析了代表性药物非临床和临床安全性数据的关联性，解析了代表性药物主要毒性发生的机制，最后展望了同类靶点药物研发的前景。 本书不仅为新药研发人员提供了有关靶向药物的详细研究信息，也为临床医生提供了各类靶向治疗药物的安全性资料，可供相关领域科研人员参考。", "item_img_path" : "https://covers4.booksamillion.com/covers/bam/7/54/786/404/754786404X_b.jpg", "price_data" : { "retail_price" : "65.99", "online_price" : "65.99", "our_price" : "65.99", "club_price" : "65.99", "savings_pct" : "0", "savings_amt" : "0.00", "club_savings_pct" : "0", "club_savings_amt" : "0.00", "discount_pct" : "10", "store_price" : "" } }

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