The Serotonin Receptors : From Molecular Pharmacology to Human Therapeutics
Overview
A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
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Details
- ISBN-13: 9781588295682
- ISBN-10: 1588295680
- Publisher: Humana
- Publish Date: June 2006
- Dimensions: 9.18 x 6.26 x 1.33 inches
- Shipping Weight: 2.2 pounds
- Page Count: 618
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