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{ "item_title" : "New Method Development and Validation of Bempedoic Acid", "item_author" : [" Sridevi Ranjitha Karanam", "Srinivasa Rao Yarguntla", "Vara Prasada Rao Kollabatthula "], "item_description" : "A Visible Spectrophotometric method has been developed and validated for the quantitative measurement of Bempedoic acid in bulk and tablet dosage forms. The process is based on the production of a colored complex in the presence of Ferric chloride between Bempedoic acid and MBTH (3-methyl-2-benzothiazolinone Hydrazone). At 663 nm, the colored complex was spectrophotometrically measured. The correlation coefficient (r2) of 0.999 revealed that the approach is linear in the concentration range of 10-60g/mL. It was discovered that the limits of detection (LOD) and quantitation (LOQ) were 2.169g/mL and 6.572g/mL, respectively. For both intra-day and inter-day precision studies, the approach was proven to be precise with a percent relative standard deviation (%RSD) less than 2.0%. Recovery experiments were used to assess the method's accuracy, and it was discovered that the average percentage of recovery fell between 98.0 and 102.0%. The results of the suggested approach were compared to those of the reference method for the accurate determination of Bempedoic acid in tablet dosage forms.", "item_img_path" : "https://covers1.booksamillion.com/covers/bam/6/20/822/356/6208223563_b.jpg", "price_data" : { "retail_price" : "47.00", "online_price" : "47.00", "our_price" : "47.00", "club_price" : "47.00", "savings_pct" : "0", "savings_amt" : "0.00", "club_savings_pct" : "0", "club_savings_amt" : "0.00", "discount_pct" : "10", "store_price" : "" } }
New Method Development and Validation of Bempedoic Acid|Sridevi Ranjitha Karanam

New Method Development and Validation of Bempedoic Acid

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Overview

A Visible Spectrophotometric method has been developed and validated for the quantitative measurement of Bempedoic acid in bulk and tablet dosage forms. The process is based on the production of a colored complex in the presence of Ferric chloride between Bempedoic acid and MBTH (3-methyl-2-benzothiazolinone Hydrazone). At 663 nm, the colored complex was spectrophotometrically measured. The correlation coefficient (r2) of 0.999 revealed that the approach is linear in the concentration range of 10-60 g/mL. It was discovered that the limits of detection (LOD) and quantitation (LOQ) were 2.169 g/mL and 6.572 g/mL, respectively. For both intra-day and inter-day precision studies, the approach was proven to be precise with a percent relative standard deviation (%RSD) less than 2.0%. Recovery experiments were used to assess the method's accuracy, and it was discovered that the average percentage of recovery fell between 98.0 and 102.0%. The results of the suggested approach were compared to those of the reference method for the accurate determination of Bempedoic acid in tablet dosage forms.

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Details

  • ISBN-13: 9786208223564
  • ISBN-10: 6208223563
  • Publisher: LAP Lambert Academic Publishing
  • Publish Date: October 2024
  • Dimensions: 9 x 6 x 0.18 inches
  • Shipping Weight: 0.27 pounds
  • Page Count: 76

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